What to expect when starting GLP-1s for weight loss

Wellbeing

Starting GLP-1 medications can be exciting but might come with a lot of questions. What will it feel like? How soon will you start seeing changes?

Getting a sense of what to expect, how to handle any side effects, and how to fit GLP-1s into your daily routine can make the entire process much smoother.

Here’s a clear guide to help you navigate what’s ahead, manage any bumps along the way, and make GLP-1s fit seamlessly into your life. 

What are GLP-1s?

GLP-1s (glucagon-like peptide-1 receptor agonists) are a class of medications that were initially designed to manage type 2 diabetes but are now also used to help with weight management. These medications mimic the GLP-1 hormone in your body, regulating appetite and digestion while balancing blood sugar levels.

GLP-1s work by:

• Slowing down how fast food leaves your stomach. This keeps you feeling full longer.
• Reducing appetite, making it easier to consume fewer calories.
• Enhancing insulin release when your blood sugar is high

One popular GLP-1 medication you might recognize is semaglutide, known by the brand name Ozempic. It’s typically taken once a week.

What you can expect in the first few weeks

The first few weeks of starting GLP-1s can feel like an adjustment period. Here’s what you might notice:

• Side effects: Mild side effects are common as your body gets used to the medication. You might experience nausea, bloating, or fatigue. However, these symptoms are temporary and resolve within a few weeks. If you experience concerning symptoms, contact your doctor. 

• Changes in appetite: One of the signs that GLP-1s are working is a noticeable drop in hunger. You may feel full with smaller meals. If you don’t notice this right away, don’t worry — it sometimes takes a higher dose for these effects to kick in. Your doctor will gradually increase your dose until it feels effective. 

• Shifts in energy levels: Some people report feeling more energized as they lose weight, while others may initially feel more tired. Listen to your body and pace yourself through any periods of low energy.

• Gradual dosage increase: Most healthcare providers start you off with a low dose and gradually increase it over a few months. This helps your body adjust and minimizes side effects. ¹

How to manage the side effects

Dealing with side effects can be uncomfortable, but most symptoms fade after a few weeks as your body adapts. Here are some tips for managing side effects:

• Light, balanced meals: Stick to smaller, nutritious meals that are easier on your stomach. Heavy, greasy foods can worsen nausea or bloating, so aim for dishes with protein, fiber, and healthy fats. Think grilled chicken salads or avocado toast instead of burgers and fries. 

• Eat slowly: Take your time when eating to help your body better digest food and reduce any potential discomfort. Savoring meals can also help with portion control.

• Communicate with your doctor: If side effects don’t ease up or you feel too uncomfortable, reach out to your doctor. They might adjust your dosage or suggest additional strategies to manage your symptoms.

How to fit GLP-1s into your life

Sticking with your GLP-1 treatment is essential for getting the best results. The medication builds up in your system over time, so consistency is key. Here’s how to make it easier to stay on track:

• Set up reminders: Use alarms to remind you of your weekly dose.

• Build a routine: Taking your medication at the same time each week helps create a habit. Pair it with something you already do, like brushing your teeth or having breakfast. 

• Plan for travel: If you’re heading out of town, don’t forget to pack your medication and any supplies like needles or a sharps container. 

• Support your progress: While GLP-1s are effective, they work best when combined with healthy habits. ¹ Find a type of exercise you enjoy, like walking or yoga, and add it to your routine to amplify your results. 

When will you see results? Here’s what to expect

Results can vary from person to person, so don’t worry if your journey looks different from others. Here’s what you can expect:

• Dosage adjustments: While some people might start seeing results at a 1 mg dose, others may need a higher dose to get noticeable weight loss. It typically takes about three to four months of slowly increasing your dose to reach these higher dosages. During this time, you may notice gradual changes.

• Steady weight loss: Weight loss won’t happen overnight. Once you’re on the right dose, most people see steady, consistent results over the following months. Even if the scale doesn’t move as fast as you’d like, remember that slow and steady weight loss tends to be more sustainable in the long run.

• Expect plateaus: It’s normal for weight loss to slow down or plateau as your body adjusts. Don’t be discouraged; this is a natural part of the process. If you hit a long plateau, talk to your healthcare provider. They may recommend adjusting your dose or trying new strategies to keep things moving forward. ¹ 

Final tips

Starting GLP-1s for weight loss can feel like a big change, but knowing what to expect helps you stay motivated and committed. The initial adjustment period may come with side effects, but they’re usually temporary and subside after a few weeks. 

And remember, while GLP-1s are powerful weight loss tools, they work best when combined with healthy lifestyle choices. Eating balanced meals, staying hydrated, and finding enjoyable ways to move your body can maximize the benefits of your treatment and lead to long-term success.